Endocrine Abstracts

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ea0021p127 | Cytokines and growth factors | SFEBES2009

Atrophy or hypertrophy: differential responses of C₂ and C₂C₁₂ mouse skeletal myoblasts in the absence or presence of tumour necrosis factor-α (TNF-α)

Sharples Adam , Al-Shanti Nasser , Stewart Claire

Inflamed ageing is associated with reduced muscle mass and increased susceptibility to TNF-induced muscle protein degradation. We therefore aimed to elucidate mechanisms supporting reduced hypertrophy and increased atrophy of skeletal myoblasts. C2 myoblasts display diminished differentiation and increased susceptibility to TNF-α-induced apoptosis versus daughter C2C12 cells, providing us with relevant models. C2 and C2</su...

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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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Endocrine Abstracts

Atrophy or hypertrophy: differential responses of C2 and C2C12 mouse skeletal myoblasts in the absence or presence of tumour necrosis factor-α (TNF-α)

BiosciAbstracts

Atrophy or hypertrophy: differential responses of C₂ and C₂C₁₂ mouse skeletal myoblasts in the absence or presence of tumour necrosis factor-α (TNF-α)